Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation
Effect of TubA on HDAC6 activity, total Prdx1, and Ac-Prdx1 in diabetic rats. D: STZ-induced diabetic rats; S: sham operation; IR: ischemia/reperfusion; TubA: tubastatin A. (a) HDAC6 activity was measured by fluorometric assay kit. (b) Total Prdx1 level of myocardium was analyzed by Western blot. GAPDH served as the loading control. (c) Acetylation level of Prdx1 was analyzed by immunoprecipitation. All values are presented as the mean ± SEM, /group. versus DIR group, versus DS group.
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