2,3,5,4-Tetrahydroxystilbene-2-O-beta-D-glucoside Reverses Stress-Induced Depression via Inflammatory and Oxidative Stress Pathways

Figure 1

THSG alleviated depression-related behaviors in CRS-induced model mice. Model mice were exposed to CRS for 4 weeks according to the timeline (a), and different concentrations of THSG were administered for 2 weeks. The behavior tests were carried out after THSG (10 mg/ml, 20 mg/ml, and 40 mg/ml), vehicle, and fluoxetine (10 mg/ml) treatment. The changes in mouse body weights are shown in (b). The immobility times in the TST and FST are shown in (c, d, e). The distances and times of mouse locomotor activity in the OFT are shown in (f, g). Values are expressed as the mean ± SEM, with 10 mice in the control + Veh group and 9 mice in the other groups. For statistical significance, , , and versus the control + Veh group; , , and versus the CRS + Veh group.

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