2,3,5,4-Tetrahydroxystilbene-2-O-beta-D-glucoside Reverses Stress-Induced Depression via Inflammatory and Oxidative Stress Pathways

Table 1

The effect of THSG treatment on antioxidant ability in serum, hippocampus, and PFC tissues of mice.

Item	Sample	Groups ()
		Control + Veh	CRS + Veh	CRS + L-THSG	CRS + M-THSG	CRS + H-THSG	CRS + FH
MDA	Serum (μmol/l)	18.86 ± 1.75	23.50 ± 1.80	14.75 ± 1.32^###	16.18 ± 1.39^##	17.06 ± 1.25^##	20.13 ± 1.43
	Hip (μmol/mg)	0.65 ± 0.04	0.79 ± 0.03	0.58 ± 0.03^###	0.47 ± 0.02^###	0.64 ± 0.05^#	0.66 ± 0.03^##
	PFC (μmol/mg)	0.84 ± 0.04	0.94 ± 0.04	0.88 ± 0.02	0.84 ± 0.04^#	0.72 ± 0.03^###	0.81 ± 0.05^#
GSH-PX	Serum (U/ml)	905.1 ± 64.37	1089 ± 31.64	1128 ± 37.38	892.7 ± 50.81^##	749.2 ± 78.05^##	918.3 ± 36.97^##
	Hip (U/mg)	169.1 ± 8.45	143.3 ± 6.73	145.7 ± 13.15	163.4 ± 13.01	176.3 ± 10.08^#	178.6 ± 15.57^#
	PFC (U/mg)	215.2 ± 15.37	320.3 ± 54.46	280.9 ± 42.50	200.5 ± 19.26^#	249.5 ± 38.14	224.2 ± 17.13^#
T-AOC	Serum (U/ml)	5.12 ± 1.05	6.11 ± 0.44	5.50 ± 0.52	5.34 ± 0.74	4.40 ± 0.50^#	5.56 ± 0.58
	Hip (U/mg)	0.188 ± 0.039	0.258 ± 0.09	0.222 ± 0.017	0.161 ± 0.012^##	0.205 ± 0.039	0.201 ± 0.029^#
	PFC (U/mg)	0.24 ± 0.047	0.26 ± 0.046	0.16 ± 0.014^#	0.10 ± 0.012^##	0.19 ± 0.052	0.15 ± 0.049^#

Note: MDA: malondialdehyde; GSH-PX: glutathione peroxidase; T-AOC: total antioxidant capacity; Hip: hippocampus; PFC: prefrontal cortex. Effect of THSG treatment on the antioxidant abilities in mouse serum, hippocampal tissue, and cortex tissue. Peripheral serum samples were collected from the retroorbital vessel after drug administration, and the hippocampal and prefrontal cortex tissues were dissected after the mice were sacrificed. The MDA content and GSHPX and T-AOC activities in serum are expressed as μmol/l, U/ml, and U/ml, respectively, while those values in the hippocampal and prefrontal cortex tissues are expressed as μmol/mg, U/mg, and U/mg, respectively. Values are expressed as the mean ± SEM, with 10 mice in the control + Veh group and 9 mice in the other groups. For statistical significance, and versus the control + Veh group; , , and versus the CRS + Veh group.