Nocturnal Hypoxia Improves Glucose Disposal, Decreases Mitochondrial Efficiency, and Increases Reactive Oxygen Species in the Muscle and Liver of C57BL/6J Mice Independent of Weight Change

Table 2

Glucose transporter (GLUT1–4) expression relative to β-actin in the muscle and liver after two-week exposure to room air (Air), nocturnal 10% hypoxia (N10%), and continuous 10% hypoxia (C10%) in lean and obese mice. Data shown as mean ± s.e.m. Two-way ANOVA showed increased GLUT1 expression for obese mice relative to lean mice in both muscle (F(1,12) = 13.4; ) and liver (F(1,12) = 10.2; ).

			Air	N10%	C10%
Muscle	GLUT1	Lean	0.32 ± 0.04	0.27 ± 0.03	0.28 ± 0.02
		Obese	0.33 ± 0.04	0.48 ± 0.04	0.45 ± 0.03
	GLUT4	Lean	0.42 ± 0.02	0.39 ± 0.01	0.43 ± 0.04
		Obese	0.34 ± 0.03	0.38 ± 0.03	0.39 ± 0.04
Liver	GLUT1	Lean	0.31 ± 0.02	0.32 ± 0.05	0.29 ± 0.02
		Obese	0.51 ± 0.11	0.60 ± 0.11	0.54 ± 0.09
	GLUT2	Lean	0.50 ± 0.04	0.46 ± 0.06	0.51 ± 0.07
		Obese	0.47 ± 0.01	0.37 ± 0.01	0.44 ± 0.07
	GLUT3	Lean	0.71 ± 0.14	0.70 ± 0.13	0.70 ± 0.16
		Obese	0.64 ± 0.15	0.57 ± 0.15	0.52 ± 0.08