Granulocyte Colony-Stimulating Factor Alleviates Bacterial-Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification
Impairment of the long-term performance of working and cued reference memory was found using an eight-arm radial maze task after LPS exposure. (a) One trial/day over 15 trials and average amount of working memory errors. The inset box reveals the average total mean working memory errors. (b) One trial/day over 15 trials and average amount of cued reference memory errors. The inset box reveals the average of total mean reference memory errors. Control group ( animals), G-CSF group ( animals), LPS group ( animals), and LPS + G group ( animals) are labeled as C, LPS, G, and LPS + G, respectively. Statistical analysis of the long-term performance of the working and cued reference memory revealed that the rats in the LPS group significantly differed from those in the vehicle-control and LPS + G groups. compared with the control group. compared with the LPS group
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