Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response

Table 1

Differential regulation of proinflammatory cytokine production by UPR-TLR interaction.

Signaling components of TLR	Interacting UPR branches	Cytokines
NF-kappaB	PERK	IL-6, IL-1β, TNF-α, IL-8
TLR2	ATF4	IL-6, TNF-α, IL-8
ERK	CHOP	IL-6, TNF-α
NF-kappaB	IRE1α	IL-6, IL-1β, TNF-α, IL-8
TRAF2-NOD1/2		IL-6
TRAF2-GSK/JNK/p38		IL-6, TNF-α, IL-8, MCP-1
TRAF2-IKK		IL-6, TNF-α, IL-8, IL-2
TRAF6		IL-6, TNF-α
GSK-3β		IL-1β
NF-kappaB	ATF6	IL-6, IL-1β, TNF-α, IL-8
p38		IL-6,IL-8