Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties

Table 1

Values of IC₅₀ for AChE, AChE in the presence of iso-OMPA (10⁻⁵ M) and BChE activities, and DPPH free radical formation of CHE and OFs (HF, CF, EAF, and BF) of C. brasiliense leaves. Values of EI and total phenolic content (GAE) to the samples are listed as well.

	AChE (μg/mL)	AChE + iso-OMPA (μg/mL)	BChE (μg/mL)	DPPH (μg/mL)	EI (μA/V)	GAE (mg/mL)
CHE	202.4 ± 7.9	233.6 ± 12.2	204.3 ± 12.4	4.6 ± 1.0	46.6 ± 3.9	1.2 ± 0.3
HF	ND	ND	ND	25.6 ± 1.5	27.3 ± 2.5	0.6 ± 0.1
CF	ND	ND	ND	76.4 ± 0.4	4.4 ± 0.5	0.1 ± 0.1
EAF	81.5 ± 14.7	128.9 ± 16.8	118.6 ± 11.3	5.9 ± 0.2	119.8 ± 4.0	4.0 ± 0.2
BF	235.9 ± 17.4	292.5 ± 22.3	225.7 ± 15.2	9.3 ± 0.6	58.1 ± 2.7	1.9 ± 0.3

Values are expressed as mean ± SEM of three experiments. , , and when compared with CHE. ND: not determined.