Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling

Figure 4

Troxerutin inhibited TXNIP and ameliorated kidney function in BDE-47 mice. (a) TXNIP expression was detected by western blot analysis. The relative density is normalized to β-actin. and , respectively, means versus the BDE-47 group (). (b) shows renal TXNIP immunofluorescence (Leica 4000, ×40). Nuclei were stained with DAPI (blue fluorescence). Scale bar, 50 μm. White arrows indicate positive signal which was placed in the upper right corner (red). (c) TXNIP siRNA decreased ACR in BDE-47-treated mice. TXsi means TXNIP siRNA, and Scr means scramble. and versus the adjacent groups (). (d) TXNIP siRNA suppressed the activity of kidney NLRP3 inflammasome in BDE-47-treated mice. , , and versus the adjacent groups (). (e) TXNIP siRNA decreased the activity of NF-κB, iNOS, and COX-2. , , and versus the adjacent groups ().

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