Oxidative Medicine and Cellular Longevity / 2019 / Article / Tab 2

Research Article

Intracellular Neuroprotective Mechanisms in Neuron-Glial Networks Mediated by Glial Cell Line-Derived Neurotrophic Factor

Table 2

Analysis of cell viability in primary hippocampal cultures under the inhibition of intracellular kinases in hypoxia modelling.

GroupNumber of viable cells on day 7 after inhibitor application (%)Number of viable cells on day 7 after inhibitor and GDNF application (%)

Sham
Hypoxia
Hypoxia+GDNF
Hypoxia+RET kinase inhibitor
Hypoxia+RAF kinase inhibitor
Hypoxia+MAP2K1/2, Erk2, RAF kinase inhibitor
Hypoxia+AKT1 kinase inhibitor
Hypoxia+Jak1, Jak2 kinase inhibitor

The data represent the from six independent experiments. Statistical significance was calculated by one-way ANOVA; versus “Sham”; #versus “Hypoxia”; &versus “Hypoxia+GDNF”.