Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response

<div>HL-7702 cells were treated with various concentrations of matrine for 48 h. (a) Apoptosis detection with Annexin V-FITC/PI double staining in different groups by flow cytometry. The Q3 region represents viable cells, while the Q4 region represents early apoptotic cells. The Q2 region represents late apoptotic cells, while the Q1 region represents necrotic cells or mechanical damaged cells. (b) Column bar graph of mean cell florescence for viable, early apoptotic, and late apoptotic cells. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 

Figure 3 | Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 