Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response

<div>Effect of matrine on the distribution of HL-7702 cells among phases of the cell cycle. (a) Matrine induced cell cycle arrest at the S phases. (b) Each phase of the cell cycle was shown in a polyline diagram. (c) The expression levels of the correlative proteins were measured by western blot. <i>β</i>-Actin was used as a loading control. (d) Densitometric analysis was used to quantify these protein-related bands and statistically analyze. 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Oxidative Medicine and Cellular Longevity

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Figure 4

Figure 4: Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 

Figure 4 | Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 