Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response

<div>Effects of matrine on Nrf2 pathway. (a) The effects of matrine on the expression levels of Nrf2, Keap1, HO-1, and NQO-1 were measured by western blot after treatment with various concentrations of matrine for 48 h. (b) Densitometric analysis was used to quantify these protein-related bands (Nrf2, Keap1, HO-1, and NQO-1) and statistically analyze. (c) Effect of matrine on the formation of Keap1/Nrf2 complex. (d) Western blot analysis of Nrf2. HL-7702 cells were treated with matrine (0–4 mg/mL) for 48 h. The whole-cell lysates were analyzed by western blot analysis with the indicated antibodies. 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Oxidative Medicine and Cellular Longevity

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Figure 8

Figure 8: Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 

Figure 8 | Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 