Excessive Neutrophil Extracellular Trap Formation Aggravates Acute Myocardial Infarction Injury in Apolipoprotein E Deficiency Mice via the ROS-Dependent Pathway

Figure 1

The role of ApoE deficiency in ischemic injury. (a, b) Representative TTC staining and quantitation of the infarct size of ApoE^-/- and WT mice 1 day after ligation. Each group involves data of 6 mice. (c) Serum levels of cTnI and CK-MB of ApoE^-/- and WT mice without surgery (Ctrl) or 1 day after ligation (MI). Each Ctrl group involves the data of 6 mice, and each MI group involves the data of 8 mice. (d, e) Representative echocardiographic images and quantitation of heart rate, left ventricle ejection fraction (LVEF), and fractional shortening (FS) of ApoE^-/- and WT mice without surgery (Ctrl) or 7 days after ligation (MI). Each Ctrl group involves 6 mice, and each MI group involves 8 mice. Data are shown as . Statistical tests include the two-tailed Student’s -test (two groups) and one-way analysis of variance followed by Tukey’s multiple comparison test (more than two groups). and .

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