L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells

<div>Effect of L-Cth on mitochondrial membrane potential and mitochondrial permeability transition pore (MPTP) opening in Hcy-treated HUVECs. (a) Change of mitochondrial membrane potential detected by a JC-1 fluorescent probe, with red fluorescence indicating high mitochondrial membrane potential and green indicating low mitochondrial membrane potential (magnification, ×600; scale bar: 20 <i>μ</i>m). (b) Changes of MPTP opening in HUVECs detected with calcein AM. The green fluorescence quenching represented MPTP opening (magnification, ×600; scale bar: 20 <i>μ</i>m). L-Cth: L-cystathionine.</div>

Oxidative Medicine and Cellular Longevity

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Figure 4

Figure 4: L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells 