Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors

Figure 1

Experimental design. (a) Two-month-old female R1.P1-Apoa2c mice were divided into 4 groups: control (Con), no treatment (A-NT), tempol (Tem), and apocynin (Apo). AApoAII amyloidosis was induced in the mice in the A-NT, Tem, and Apo groups by injection with 1 μg AApoAII fibrils in the tail vein; the Con group was injected with distilled water instead of AApoAII fibrils. Concomitantly, the Tem and Apo group mice were treated with either tempol (1 mM) or apocynin (1.5 mM) in drinking water for 8 or 12 weeks (–7 per group). (b) In the high-dose series, the experiment was repeated with double doses of tempol (2 mM) or apocynin (3 mM) and the experimental period was 12 and 16 weeks ( or 5 per group).

(a)

(b)