Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease

Figure 1

(a) Schematic diagram of full-length SESN2 showing the three domains SESN-A, SESN-B, and SESN-C. (b) Schematic representation of SESN2 showing the localization of the catalytic cysteine (C125) and conserved residues of the proton relay system (Y127 and H132) in the SESN-A domain, the characteristic aspartate-aspartate (DD) motif, and the Leu binding site in the SESN-C domain (based on structure analysis published by Ho et al. in reference [12], Figure 1, doi:10.1016/j.tibs.2016.04.005). (c) Schematic representation of SESN2 showing direct interactors and pathways involved.

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