Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease

Figure 2

SESNs are master regulators of antioxidant defences. SESNs may be induced upon intracellular oxidative stress by the stimulation of transcription factors, such as p53, Nrf2, AP-1, and FoxOs. Once activated, SESNs limit ROS and oxidative stress by multiple mechanisms, thus having a functional role in age-related diseases as well as cancer.