Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease

Table 1

Some examples of the cytoprotective effect by SESNs.

Entry	Drugs or toxic substances	Cell lines	Tissue type/model organism	Effect on SESNs	Molecular mechanisms	Biological effect	Refs
1	Amyloid β-peptide	Primary rat cortical neurons	Transgenic mice	SESN2 ↑	LC3B-II ↑	Protective autophagy, prevention of neuronal cell death, protection against Alzheimer’s disease	[41]
2	Sevoflurane	M17	Neuroblastoma	SESN2 ↑	p53-dependent mechanism	Prevention of neuroapoptosis and ROS	[88]
3	1-Methyl-4-phenylpyridinium	SH-SY5Y	Neuroblastoma	SESN2 ↑	p53-dependent mechanism	Protection against oxidative stress, mitochondrial dysfunction, apoptosis, and cell death and protection against Parkinson’s disease	[92]
4	Chromium IV	Neuronal cells	Drosophila melanogaster larvae	dSESN ↑	ATG-8 ↑, p-JNK, p-Akt, p-FoxO, cleaved caspase-3 ↓, TOR/p-S6k ↓	Protection against oxidative stress, apoptosis, and neuronal cell death and protective autophagy	[97]
5	Angiotensin II	HUVECs	Endothelial	SESN2 ↑	JNK/c-Jun pathway ↑	Protection against cardiotoxicity of angiotensin II	[102]
6	Acetaminophen	Liver cell	Mice	SESN2 ↑	JNK, ERK pathway ↓, p38 ↓	Inhibition of oxidative stress, proinflammatory signalling, protection against liver toxicity	[103]