Scutellarin Exerts Hypoglycemic and Renal Protective Effects in db/db Mice via the Nrf2/HO-1 Signaling Pathway

Table 2

The regulatory effects of SCU and Met on the levels of inflammatory cytokines.

		db/m^+	db/db	db/db + Met (mg/kg)	db/db + SCU (mg/kg)
				120	25	50	100
Serum	GSK (pmol/L)	490.9 ± 13.6	570.5 ± 17.8^##	446.4 ± 10.7	510.4 ± 15.6	496.1 ± 23.1	502.1 ± 12.8
	ICAM-2 (nmol/mL)	29.4 ± 0.6	35.2 ± 1.4^#	26.6 ± 1.6	19.3 ± 1.6	23.3 ± 0.9	25.8 ± 1.2
Kidney	IL-1β (pg/mgprot)	34.1 ± 2.1	37.2 ± 2^#	34.5 ± 1.6	31.8 ± 2.4	34.2 ± 2.1	35.1 ± 0.5
	IL-2 (pg/mgprot)	74.4 ± 3	84.8 ± 4.4^#	85.8 ± 2.6	72.8 ± 5	73.3 ± 1.1	65.3 ± 2.3
	IL-4 (pg/mgprot)	37.9 ± 1.6	32.5 ± 2.1^#	40.5 ± 0.6	43.4 ± 4.2	33.8 ± 1.3	37.7 ± 1.2

and versus db/m⁺ mice, , , and versus vehicle-treated db/db mice.