Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis

Figure 1

IL-17 signaling pathway in the small intestinal muscularis propria in normal mice and septic mice. Microarray-based genome-wide gene expression profiles were investigated 48 h after CLP. (a) The results showed the top ten enrichment score (-log10 ( value)) values of the upregulated and the downregulated genes and significant enrichment pathways. (b) The significantly upregulated genes related to the IL-17 signaling pathway (heat map) in septic mice. The higher the enrichment score is, the more significant the pathway, in each group. (c) Real-time PCR analysis for the validation of selected gene expression patterns. (d) Comparison of the protein expression of IL-17A in the muscularis propria between normal mice and septic mice (data are shown as the , to 4, ).

(a)

(b)

(c)

(d)