Research Article
A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration
Figure 2
Quercetin-SD more potently improves retina pathological changes in Nrf2 WT mice model of dry AMD. (a) Transmission electron microscopy examination of mouse eye tissues (magnification ×25000). Arrows are used to indicate sediment, and asterisks to indicate Bruch’s membrane. (b) Deposit severity score for RPE sediments. (c) Quantification of Bruch’s membrane thickness. Significance: Nrf2 WT versus Nrf2 KO in the aging control and model control; ※, ※※ model control versus aging control; # Q-SD 200 versus model control; &, && versus model control; @ Q-SD 200 versus Q-PC 200 or Q-SD 100 ().
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