Methylene Blue-Mediated Photodynamic Therapy Induces Macrophage Apoptosis via ROS and Reduces Bone Resorption in Periodontitis

Figure 6

MB-PDT targeted macrophages through electrostatic attraction. MB was cationic and could be attracted by negatively charged bacterial LPS, which made contact with TLR4 in macrophages when periodontitis developed. Therefore, MB could aggregate in macrophages.