Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

<div>Aa treatment led to the collapse of oxidative phosphorylation in ARPE-19 cells and induced a shift towards glycolysis. Treatment with 1 <i>μ</i>M, 10 <i>μ</i>M, and 20 <i>μ</i>M Aa led to a rapid and major reduction in the oxygen consumption rate (OCR) (a, b) and an increase in the extracellular acidification rate (ECAR) (a, c) in ARPE-19 cells, as measured on an XFe Extracellular Flux Analyzer. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy 