|
Model | Target | Response |
Biomarker | Molecular identity |
|
Human gingival fibroblasts | COX-1/2 | Inflammatory mediators | Downregulated by TCS |
5/15-LPO | Downregulated by TCS |
PGE2 | Downregulated by TCS |
PGI2 | Downregulated by TCS |
Arachidonic acid | Downregulated by TCS |
PLA2 | Downregulated by TCS |
PGE synthase-1 | Downregulated by TCS |
IFNγ | Immune/inflammatory cytokines | Downregulated by TCS |
IL-1β | Downregulated by TCS |
MHC II | Cell surface proteins; adaptive immunity regulators | Downregulated by TCS |
Cox2 | Inflammatory mediator | Downregulated by TCS |
Il6 | Immune/inflammatory cytokines | Downregulated by TCS |
Il1b | Downregulated by TCS |
Tlr6 | Innate immunity receptor | Upregulated by TCS |
|
Human primary oral epithelial cells | IL-8 | Immune/inflammatory cytokines | Downregulated by TCS |
IL-1α | Downregulated by TCS |
TNFα | Downregulated by TCS |
miR146a | Transcriptional regulators of TLR response | Upregulated by TCS |
miR155s | Downregulated by TCS |
|
Mouse skin and leukocytes | S100A8/A9 | Inflammatory modulator; Ca2+-binding protein | Upregulated by TCS |
Tlr4 | Innate immunity receptors | Upregulated by TCS |
TLR4 | Upregulated by TCS |
Tlr1 | Upregulated by TCS |
Tlr2 | Upregulated by TCS |
Tlr6 | Upregulated by TCS |
|
Rat osteoblastic osteosarcoma cells | MMP-13 | Endopeptidase; collagen degradation | Downregulated by TCS |
|
Human oral fluids | IL-1α | Immune/inflammatory cytokines | Downregulated by TCS |
IL-1β | Sensitive to TCS |
IL-8 | Sensitive to TCS |
MCP-1 | Sensitive to TCS |
TIMP-2 | MMP regulator proteins | Sensitive to TCS |
TIMP-1 | Downregulated by TCS |
MMP-8/9 | Endopeptidases; extracellular matrix degradation | Downregulated by TCS |
|
Human urine | IL-6 | Immune/inflammatory cytokines | Upregulated by TCS |
Sprague-Dawley rats | TNFα | Upregulated by TCS |
IL-6 | Upregulated by TCS |
|
Human whole blood leukocytes | Csf2 | Hematopoietic stem cell growth and maintenance | Downregulated by TCS |
Ifna1 | Immune/inflammatory cytokines | Downregulated by TCS |
Ifna2 | Downregulated by TCS |
Ifna4 | Downregulated by TCS |
Ifna8 | Downregulated by TCS |
Il-1f10 | Downregulated by TCS |
Il-1f5 | Downregulated by TCS |
Il-1f7 | Downregulated by TCS |
Il-1f8 | Downregulated by TCS |
Il-1f9 | Downregulated by TCS |
Il-6 | Downregulated by TCS |
Il-11 | Downregulated by TCS |
Il-13 | Downregulated by TCS |
Il-25 | Downregulated by TCS |
Il-19 | Downregulated by TCS |
Il-21 | Downregulated by TCS |
Il-9 | Downregulated by TCS |
Cd70 | Cell surface receptor/ligand; activated lymphocytes | Downregulated by TCS |
Bmp2 | Growth factors; bone and cartilage development | Upregulated by TCS |
Bmp6 | Upregulated by TCS |
Tnfrsf11b | TNFSF11 receptor | Downregulated by TCS |
Gdf3 | Growth/differentiation factors | Downregulated by TCS |
Gdf2 | Downregulated by TCS |
Gdf5 | Downregulated by TCS |
Gdf9 | Downregulated by TCS |
Inhba | Hypothalamus-pituitary axis regulator | Downregulated by TCS |
Lefty2 | Left-right determination factor 2; left-right asymmetry of organs | Downregulated by TCS |
|
Sprague-Dawley rats | TNFα | Immune/inflammatory cytokine | Upregulated by TCS |
IL-6 | Upregulated by TCS |
|