Enhancement by Hydrogen Peroxide of Calcium Signals in Endothelial Cells Induced by 5-HT1B and 5-HT2B Receptor Agonists

Figure 6

(a) Increase in the fluorescence of DCFH in HUVEC in control conditions, with the addition of exogenous H₂O₂ (200 μM), BW723C86 (100 μM), or CGS12066B (100 μM). The data of one of four independent experiments are presented. (b) Inhibition of BW723C86-induced formation of ROS by inhibitor of NADPH oxidase VAS2870. The concentrations were H₂O₂ 200 μM, BW723C86 and CGS12066B 100 μM, and VAS2870 10 μM.

(a)

(b)