Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology
KXS inhibited the phosphorylation of Tau via the PI3K/Akt signaling pathway in vivo. Downregulation of p-PI3K, p-Akt, and p-Tau and upregulation of p-GSK-3β were shown in the rat hippocampus treated with KXS compared with those treated with a monotreatment of GR, PR, PO, and AT. The efficiency of KXS was detected (a) and quantitated (b) by western blot analysis. The expression of p-Tau (S396) in the rat hippocampus was performed with immunohistochemistry analysis (c and d). Each of the control groups were adjusted to the same level. The column diagrams marked by different letters were significant to each other at the 0.05 level according to Duncan’s multiple range test. Values were (),.