Metformin Activates the Protective Effects of the AMPK Pathway in Acute Lung Injury Caused by Paraquat Poisoning

Figure 4

Effect of MET on the oxidation index and inflammatory factors in lung tissue homogenates from rats treated with PQ. The PQ group received a single intraperitoneal injection of 30 mg/kg paraquat, while the control group received an intraperitoneal injection of the same dose of normal saline, and the MET and PQ+MET groups received intragastric treatment with 400 mg/kg MET (once per day for 7 days) 2 hours after model establishment. The lung tissue of the rats was homogenized at a ratio of 9/1 (normal saline/lung tissue) and centrifuged at 3000 rpm and 4°C for 20 min, and the supernatant was analyzed by a relevant ELISA and a chemical kit. Data are shown as the ; SOD: , ; GSH-Px: , ; MDA: , ; IL-1β: , ; IL-6: , ; TNF-α: , ; vs. control group, vs. PQ group.

(a) Oxidation index

(b) Inflammatory factor