Metformin Activates the Protective Effects of the AMPK Pathway in Acute Lung Injury Caused by Paraquat Poisoning

Figure 5

Effect of MET on the expression of phospho-AMPK and phospho-NF-κBp65 protein in the lung tissue of rats treated with PQ. The PQ group received a single intraperitoneal injection of 30 mg/kg paraquat, while the control group received an intraperitoneal injection of the same volume of normal saline, and the MET and PQ+MET groups received intragastric treatment with 400 mg/kg MET (once per day for 7 days) 2 hours after model establishment. Lysis buffer was added to rat lung tissue samples for protein extraction and Western blotting analysis. Data are shown as the ; (b) , ; (c) , ; vs. control group, vs. PQ group.

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