Research Article
Aberrations in Oxidative Stress Markers in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
Table 1
Summary of comparative outcomes for measurements of blood oxidative stress marker levels.
| | Cytokine | No. of studies | No. with ALS/controls | Main effect | | Heterogeneity | Publication bias | | Hedges’ (95% CI) | score | value | statistic | | value | statistic | Egger intercept | value |
| | Uric acid | 7 | 961/1185 | -0.798 (-1.117 to -0.479) | -4.906 | <0.001 | 56.034 | 6 | <0.001 | 89.292 | 0.910 | 0.750 | | 8-OHdG | 2 | 18/61 | 2.194 (0.554 to 3.835) | 2.622 | 0.009 | 6.315 | 1 | 0.012 | 84.165 | NA | NA | | MDA | 5 | 123/120 | 1.168 (0.812 to 1.523) | 6.441 | <0.001 | 5.793 | 4 | 0.215 | 30.950 | 1.61721 | 0.38172 | | GSH | 4 | 71/78 | -1.636 (-3.020 to -0.252) | -2.318 | 0.020 | 36.112 | 3 | <0.001 | 91.692 | -7.014 | 0.061 | | AOPP | 2 | 147/133 | 0.555 (0.317 to 0.792) | 4.571 | <0.001 | 0.025 | 1 | 0.875 | 0.000 | NA | NA | | Ceruloplasmin | 3 | 46/46 | -0.052 (-0.475 to 0.372) | -0.239 | 0.811 | 2.168 | 2 | 0.338 | 7.742 | 2.538 | 0.403 | | Cu | 10 | 361/471 | 0.014 (-0.337 to 0.366) | 0.080 | 0.937 | 39.670 | 9 | <0.001 | 77.313 | 0.09686 | 0.94797 | | Glutathione peroxidase | 4 | 91/110 | -0.679 (-1.732 to 0.373) | -1.265 | 0.206 | 29.687 | 3 | <0.001 | 89.895 | -4.92304 | 0.30857 | | Total cholesterol | 13 | 2161/3870 | 0.144 (-0.095 to 0.383) | 1.184 | 0.236 | 160.185 | 12 | <0.001 | 92.509 | 1.50578 | 0.44161 | | HDL | 9 | 2024/3722 | -0.198 (-0.625 to 0.228) | -0.912 | 0.362 | 345.128 | 8 | <0.001 | 97.682 | 2.99958 | 0.54140 | | LDL | 9 | 2024/3722 | 0.121 (-0.283 to 0.524) | 0.587 | 0.557 | 307.948 | 8 | <0.001 | 97.402 | 2.74193 | 0.55440 | | SOD | 5 | 96/184 | -0.203 (-0.904 to 0.497) | -0.569 | 0.569 | 22.703 | 4 | <0.001 | 82.381 | 9.11205 | 0.01197 | | Co-Q10 | 4 | 95/128 | 0.040 (-0.468 to 0.548) | 0.156 | 0.876 | 9.953 | 3 | 0.019 | 69.858 | -2.10679 | 0.75503 | | Transferrin | 5 | 954/592 | 0.244 (-0.219 to 0.707) | 1.032 | 0.302 | 50.330 | 4 | <0.001 | 92.052 | 5.24433 | 0.09393 | | Triglyceride | 8 | 1743/1633 | -0.154 (-0.622 to 0.314) | -0.645 | 0.519 | 265.560 | 7 | <0.001 | 97.364 | 4.85477 | 0.32384 |
|
|
Abbreviations: df: degrees of freedom; ALS: amyotrophic lateral sclerosis; 8-OHdG: 8-hydroxyguanosine; MDA: malondialdehyde; SOD: superoxide dismutase; AOPP: Advanced Oxidation Protein Product; LDL: low-density lipoprotein; HDL: high-density lipoprotein; Co-Q10: coenzyme-Q10; NA: not available.
|
