Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

Figure 6

Synergistic cytotoxic effect of PP7 and TMZ combination in U251 and U87-MG cells. (a, b) Cell viability of U251 cells treated with ineffective concentrations of PP7 or TMZ separately for 24 h (). (c, d) Cell viability of U251 cells treated with combinations of PP7 and TMZ for 24 h (). (e, f) Cell viability of U87-MG cells treated with ineffective concentrations of PP7 or TMZ separately for 24 h (). (g, h) Cell viability of U87-MG cells treated with combinations of PP7 and TMZ for 24 h (). (i, j) Representative images and quantification analysis show that low concentration of PP7, combined with TMZ, induced cell death in U251 cells. Solvent controls are represented as 0 μM. , . (k, l) Representative images and quantification analysis show that low concentration of PP7, combined with TMZ, induced cell death in U87-MG cells. Solvent controls are represented as 0 μM. stands for the repetition of experiments. , .

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