Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study

Table 5

Multivariate Cox regression analysis for overall survival, disease-free survival, and cancer-specific survival in patients with LSCC.

	OS		DFS		CSS
	HR (95% CI)		HR (95% CI)		HR (95% CI)
UA
	1		1		1
	1.458 (1.095-1.942)	0.010	1.504 (1.131-2.001)	0.005	1.494 (1.109-2.012)	0.008
UA/Cr ratio
UA/Cr	1		1		1
UA/Cr	1.337 (1.004-1.780)	0.047	1.376 (1.030-1.839)	0.031	1.420 (1.049-1.923)	0.023
TNM stage
I-II ()	1		1		1
III-IV ()	2.732 (2.041-3.658)	<0.001	2.871 (2.145-3.842)	<0.001	3.131 (2.301-4.260)	<0.001
T stage
T1-2 ()	1		1		1
T3-4 ()	2.404 (1.804-3.202)	<0.001	2.524 (1.896-3.361)	<0.001	2.738 (2.028-3.697)	<0.001
N stage
N0 ()
N1 ()	1		1		1
N2-3 ()	3.196 (2.172-4.702)	<0.001	3.136 (2.253-4.882)	<0.001	3.372 (2.273-5.004)	<0.001
Tumour subsite
Glottic and subglottic ()	1		1		1
Supraglottic ()	2.205 (1.641-2.963)	<0.001	2.179 (1.621-2.927)	<0.001	2.332 (1.737-3.132)	<0.001
Operation therapy
Partial laryngectomy ()	1		1		1
Total laryngectomy ()	2.371 (1.794-3.135)	<0.001	2.508 (1.897-3.316)	<0.001	2.368 (1.791-3.130)	<0.001
Tumour size
≤2 cm ()	1		1		1
>2 cm ()	2.640 (1.981-3.517)	<0.001	2.624 (1.969-3.497)	<0.001	2.724 (2.045-3.627)	<0.001
Body mass index
<22.94 (413)	1		1		1
≥22.94 (401)	0.845 (0.631-1.132)	0.259	0.842 (0.629-1.129)	0.250	0.854 (0.637-1.144)	0.289
Age
<60 ()	1		1		1
≥60 ()	1.674 (1.241-2.259)	0.001	1.585 (1.175-2.139)	0.003	1.577 (1.157-2.149)	0.004
Hypertension
No ()	1		1		1
Yes ()	1.142 (0.839-1.554)	0.397	1.137 (0.836-1.548)	0.414	1.193 (0.877-1.624)	0.262
Smoking history
No ()	1		1		1
Yes ()	1.075 (0.752-1.536)	0.692	1.082 (0.757-1.545)	0.666	1.095 (0.766-1.567)	0.618
Drinking history
No ()	1		1		1
Yes ()	1.132 (0.816-1.570)	0.459	1.129 (0.814-1.566)	0.467	1.162 (0.837-1.614)	0.369

UA: uric acid; UA/Cr ratio: uric acid/creatinine ratio.