Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model

Figure 6

The effect of Artemether treatment on spatial learning and reference memory in 3xTg-AD mice. Artemether was administered by intraperitoneal injection once a day, at low doses of 5 mg/kg and high doses of 20 mg/kg for 4 weeks. (a, b) Effect on time needed to find the hidden platform (escape latency) and distance moved during the hidden platform trial. , , and , 3xTg group versus WT group; ^#, 3xTg (Arte high) versus 3xTg group; and ^& and ^&&, 3xTg (Arte low) versus 3xTg group, were considered significantly different; ten mice per group were used for the Morris water maze. (c, d) Effect on the percent time and cross times spent by mice in a target quadrant in the probe trial. versus the WT group and ^# versus the 3xTg group were considered significantly different; ten mice per group were used for the Morris water maze.

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