miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4

<div>Inhibition of miR-181c-5p with miR-181c-5p antagomir (anti-miR-181c-5p) did not change the expression of miR-181c-5p (a) but alleviated H/R-induced H9C2 cell injury (as evidenced by reduced LDH release (b) and increased cell viability (c)) and reduced apoptosis (as evidenced by reduced ratios of cleaved/total caspase 3 and Bax/Bcl-2 (d) and attenuated TUNEL-positive apoptotic cells (e)). Scale bar: 200 <i>μ</i>m. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4 