Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway

<div>Exosome internalization and cell viability in H9C2 cells <i>in vitro</i>. (a) Representative fluorescent images of H9C2 cells incubated with PKH67-labeled huc-exo<sup>NC</sup> and huc-exo<sup>TIMP2</sup> (green) at 1 hr, 6 hrs, 12 hrs, and 24 hrs and quantitation of PKH67-positive cells. Scale bar: 50 <i>μ</i>m. (b) A percentage of viable H9C2 cells was cocultured with different concentrations of exosomes (0.1, 1, 10, and 50 <i>μ</i>g/ml) for 24 h and then analyzed with the CCK-8 kit. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway 

Figure 2 | Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway 