Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway
Exosome internalization and cell viability in H9C2 cells in vitro. (a) Representative fluorescent images of H9C2 cells incubated with PKH67-labeled huc-exoNC and huc-exoTIMP2 (green) at 1 hr, 6 hrs, 12 hrs, and 24 hrs and quantitation of PKH67-positive cells. Scale bar: 50 μm. (b) A percentage of viable H9C2 cells was cocultured with different concentrations of exosomes (0.1, 1, 10, and 50 μg/ml) for 24 h and then analyzed with the CCK-8 kit. OD540: optical density at 540 nm. and .
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