CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells’ Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy

Figure 1

CIAPIN1 protein expression in NSCLC tissues and the matched noncancerous counterparts was detected. CIAPIN1 protein expressions were observed by immunohistochemical staining in 106 cases of NSCLC specimens. Representative photographs were taken at the magnification of 400x. (a) The immune scores 0 and 1 were defined as low CIAPIN1 expression. Representative photographs with low CIAPIN1 expression were shown. (b) The immune scores 2 and 3 were defined as high CIAPIN1 expression. Representative photographs with high CIAPIN1 expression were shown. Blue was marked as the nucleus, and brown was marked as the CIAPIN1 protein. (c) CIAPIN1 expression was relatively high in noncancerous tissues observed by immunohistochemical staining. (d) The CIAPIN1 staining score was statistically higher in matched noncancerous specimens compared with NSCLC samples (). (e) Western botting analysis was further performed to confirm the higher expression of CIAPIN1 in four matched benign tissues compared with cancer tissues. , compared with control.

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