CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells’ Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy

<div>NHE1 and ERK1/2 signaling pathway might contribute to cells’ metastatic potential conferred by CIAPIN1 upregulation. (a) The NHE1 protein expression was decreased in A549 cells with CIAPIN1 upregulation. (b, c) The protein array and western blotting were conducted to detect the ERK1/2 signaling pathway changes in A549 cells with CIAPIN1 upregulation. (d) ERK1/2 phosphorylation was further modulated by the NHE1 inhibitor at the indicated time in A549 cells with CIAPIN1 overexpression. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells’ Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy 