Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?

Table 1

The effect of various combinations of ethanol (EtOH), lipoic acid (LA), and disulfiram (DSF) on the heart rhythm disturbances and mortality in rats.

Disorders	EtOH	LA+EtOH	LA	DSF	DSF+LA	DSF+LA+EtOH	DSF+EtOH
	Group A	Group B	Group C	Group D	Group E	Group F	Group G
Extrasystoles	3 min (50%)	30 min (33.3%)	None	None	None	None	None
Bradycardia	5 min (100%)	40 min (83.5%)	60 min (83.5%)	20 min (83.5%)	25 min (83.5%)	30 min (100%)	40 min (83.5%)
Atrioventricular blocks (min/%)	3/16.7; 5/16.7; 30/16.7	30/16.7	None	None	None	None	None
Death (min/%)	5/16.7; 10/50	40/16.7	None	None	None	40/33.3; 50/33.3	40/66.7

Each group comprised 6 animals (). Data are presented as a percentage of animals with the heart rhythm disturbances and mortality in rats.