SGK1 Attenuates Oxidative Stress-Induced Renal Tubular Epithelial Cell Injury by Regulating Mitochondrial Function

Figure 7

A schematic representation of the proposed mechanisms by which SGK1 regulates mitochondrial function in response to oxidative stress. Oxidative stress dynamically activates SGK1, which in turn protects cell survival through several different pathways. For example, SGK1 may phosphorylate FOXO3a and inhibit cell apoptosis [21] and SGK1 may promote mitochondrial function and mitochondrial biogenesis by phosphorylating and depressing GSK3β overactivation, which is widely proven to play dirty in mitochondrial homeostasis. However, whether SGK1 can regulate other processes of mitochondria turnover is worth further study. FOXO3a: forkhead box O3; Ub: ubiquitin; P: phosphorylation.