CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression

Figure 1

(a) High glucose inhibits DRG cell viability. DRG cell viability decreased in a dose-dependent manner with increasing concentrations of glucose. Dissociated rat DRG cells were cultured in different concentrations of glucose with 10 ng/mL NGF for 24 h and 48 h. The cell viability at 24 h with glucose concentrations of 200 mmol/L and 400 mmol/L was significantly decreased compared to the control (25 mmol/L). At 48 h, we found that the cell viability was significantly reduced at all glucose concentrations compared to the control. , compared to the control; , compared to the control. (b) Cell viability of DRG neurons in different groups after 48 h. Treatment with HG, HG+CGRP, and HG+CGRP+LY294002. , compared to the control; ^#, compared to the HG group; ^&&, compared to the HG+CGRP group.

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