Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 2

Research Article

Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Figure 2

Ber ameliorated DOX-induced oxidative stress in vivo and in vitro. (a) Ber improves cardiac enzyme antioxidative activity: (A) cardiac CAT and SOD levels in rats; (B) cardiac GSH-PX level in rats; (C) cardiac MDA level in rats. (b) Effects of Ber on the increase in ROS level induced by DOX in H9c2 cells. Intracellular ROS production was detected using flow cytometry: (A) representative flow cytometry histograms; (B) quantitative analysis of (a). The results are presented as the (). △△ vs. control group, ## vs. DOX group, and vs. Ber+DOX group.

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