Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 5

Research Article

Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Figure 5

Sirtuin 1 (SIRT1) inhibition of p66shc protects against DOX-induced oxidative stress and apoptosis in H9c2 cells. Expression of manganese superoxide dismutase (MnSOD), Bcl-xL, and cleaved caspase-3 proteins was measured by Western blotting using specific antibodies. The data are presented as the (). △△ vs. control group, ## vs. DOX group, and vs. Ber+DOX group.

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