Inhibitor 1 of Protein Phosphatase 1 Regulates Ca²⁺/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes

Figure 1

CaMKIIδ variants disordered in cardiomyocytes during H/R injury. After culture in 94% N₂, 1% O₂, and 5% CO₂ for 4 h, the cardiomyocytes were changed into 95% air and 5% CO₂. The mRNA levels of CaMKIIδA, CaMKIIδB, and CaMKIIδC of the cardiomyocytes at the start of the hypoxia and different times after reoxygenation were detected by quantitative real-time PCR. 18S was serviced as a housekeeping mRNA. Plots represent the ; . Statistical significance: compared with “the start of the hypoxia.”