Research Article

Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes

Figure 13

I1PP1 overexpression corrected CaMKIIδ alternative splicing disorders, inhibited CaMKII phosphorylation, repressed CaMKII oxidation, suppressed ROS production, and attenuated hypoxia-reoxygenation injury in the cardiomyocytes.