Lipoxin A4 Ameliorates Acute Pancreatitis-Associated Acute Lung Injury through the Antioxidative and Anti-Inflammatory Effects of the Nrf2 Pathway

Figure 1

LXA4 effectively inhibited pancreatitis and AP-ALI in mice. Animals were randomly divided into three experimental groups: the AP group (AP) treated with caerulein (50 μg/kg, 7 times, ip)+LPS (10 mg/kg, ip); the AP+LXA4 group treated with LXA4 (0.1 mg/kg, ip)+caerulein+LPS; and the control group treated with 0.9% saline (ip). (a) Representative pathological images of the pancreas (100x and 400x) and (b) histological scores were obtained to evaluate the degree of injury. Slides were evaluated by two independent investigators in a blinded manner. (c) Serum amylase levels were measured by means of iodine-amylum colorimetry. (d) Representative pathological images of the lung (100x and 400x), (e) lung injury scores, and (f) the lung wet/dry weight ratio are shown. vs. the control group. ^## vs. the AP group. AP: the acute pancreatitis group; AP+LXA4, the acute pancreatitis+Lipoxin A4 group; AP-ALI: the acute pancreatitis-induced acute lung injury; LPS: lipopolysaccharide.

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