Nitric Oxide Influences HSV-1-Induced Neuroinflammation

Figure 4

Nitric oxide protects microglia from cell death, while Fas signalling stimulates iNOS expression. (a) Percentage of apoptotic (annexin V+/propidium iodide -), secondary necrotic (annexin V+/propidium iodide+), and necrotic (annexin V-/propidium iodide+) CD11b+ cells in mixed glial cultures subjected to HSV-1 infection and treatment with the NO donor (SNP, 100 μM) and the inhibitor of iNOS (AMG, 50 μM) for 24 h. (b) Percentage of iNOS+ cells in mixed glial cultures infected with HSV-1 for 24 h. Means are expressed as for ; significant differences with , while in comparison to uninfected control, represents a significant difference with in comparison to HSV-1-infected cells.

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