Nitric Oxide Influences HSV-1-Induced Neuroinflammation

Figure 7

Nitric oxide production during HSV-1 infection adds to Aβ accumulation. (a) Representative confocal images of brains obtained at day 5 p.i. with HSV-1, with the hypothalamus and midbrains stained for HSV-1, Aβ, NeuN (neuronal marker), and iNOS. (b) Neuronal culture positive for Aβ and HSV-1. (c, d) Western blot analysis of Aβ in HSV-1-infected and control uninfected neuronal cultures subjected to treatment with the NO donor SNP (100 μM) or the inhibitor of iNOS AMG (50 μM) for 24 h. Means are expressed as the mean densitometric for . Significant differences with . Nuclei were counterstained with DAPI.

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