Research Article

Nitric Oxide Influences HSV-1-Induced Neuroinflammation

Table 1

Cytokine and chemokine expression in neuronal primary cultures.

TNF-alphaIFN-alphaCXCL9CXCL10

n.d.n.d.n.d.n.d.
n.d.n.d.n.d.n.d.
sFasLn.d.n.d.
HSV-1
n.d.
n.d.n.d.n.d.n.d.
n.d.n.d.
n.d.

Cytokine and chemokine expression changes in the neuronal cultures at 24 h p.i. with HSV-1. Neuronal cultures were subjected to treatment with the NO donor—SNP (100 μM)—and the inhibitor of iNOS—AMG (50 μM)—and sFasL (0.1 μg/ml). mRNA levels of IFN-alpha, TNF-alpha, CXCL9, and CXCL10 are shown as expression relative to control on the basis of the method. mRNA levels were counted from three PCR reactions for each sample. and versus HSV-1-infected control. n.d. means not detected.