Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies

Figure 1

Synthesis, storage, degradation, and activity of H₂S, especially in urinary cancers. H₂S has roles in different pathways of urinary cancers such as signaling or ion channel. Abbreviations: CBS: cystathionine β-synthase, CSE: cystathionine γ-lyase, 3-MPST: 3-mercaptopyruvate sulfurtransferase, Stat3/Nmpt: signal transducer and activator of transcription 3/nicotinamide phosphoribosyltransferase, HSP60: heat shock protein 60, PI3K/AKT: phosphatidylinositol 3-kinase, UC: urothelial carcinoma, RCC: renal cell cancer, PCa: prostate cancer.