Testicular Toxicity of Water Pipe Smoke Exposure in Mice and the Effect of Treatment with Nootkatone Thereon

Table 2

Frequency of Johnsen’s mean testicular biopsy score in experimental groups.

Johnsen’s score
Score	10	9	8	7	6	5	4	3	2	1
AE	31%	38%	19%	9%	2%	1%	0%	0%	0%	0%
WPS	14%	31%	35%	16%	2%	2%	0%	0%	0%	0%
NK	33%	33%	19%	11%	2%	2%	0%	0%	0%	0%
	30%	28%	26%	11%	4%	1%	0%	0%	0%	0%

The data are expressed in % of the seminiferous tubules which achieved a particular Johnsen’s score in the air exposure (AE), water pipe smoke (WPS), nootkatone (NK), and groups (-6). Nootkatone (90 mg/kg/day) was given to the mice by oral gavage for 30 days, 1 h before WPS or air exposure.