|
| Authors | Study group(s) | Cornelian cherry | Duration | Dose | Parameters and results |
|
| Sozański et al. [47] | Hyper CH rabbits | Fruit lyophysate | 60 d | 100 mg/kg BW | ↑ PPAR expression
↓ TG 44%
↓ Ao plaque
↓ ROS |
|
| Francik et al. [56] | 22-week-old Wistar rats | Freeze-dried wild fruits | 5 w | 10% of daily intake | In brain tissue
↑ catalase
↑ PON1
↑ FRAP
↓ protein carbonyl
↓ thiols |
|
| Banihabib et al. [8] | Wistar male rats, injected | Wild fruits, dried, methanol extracted powder | 16 d | 300 and 700 mg/kg BW | Kidney ↓ MDA
↑ CAT
↑ SOD
↑ GPx
↓ lipid peroxidation |
|
| Abdollahi et al. [7] | Wistar male rats | Hydromethanolic extract | 21 d | 50, 200, 400 mg/kg BW | Blood count improved in 400 mg group |
|
| Alavian et al. [63] | Wistar male rats, injected with CCl4 | Wild fruits, dried, methanol extracted powder | 16 d | 300 res. 700 mg/kg BW | ↓ hepatic markers AST, ALT, ALP
↓ hepatic lipid peroxidation |
|
| Asgary et al. [50] | DM rats (nonspecified) | Wild fruits, dried powdered | 4 w | 2 g/d | ↓ G, TCH, LDL-CH, AST, ALT, ALP comparable to glibenclamide |
|
| Celep et al. [49] | Sprague–Dawley male rats | Leaves—80% methanolic extract | 21 d | 500 mg/kg BW | In vitro—free radical scavenging+metal reducing activity
In vivo—↑ total antioxidative capacity of liver ↔ SOD, CAT, GPx, lipid peroxidation |
|
| Asgary et al. [59] | Dyslipidemic children 9-16 yrs | Wild fruits, fresh | 6 w | 100 gr fruits/d | ↓ TCH, LDL-CH, TG, apoB, I-CAM1, VCAM-1
↑ HDL-CH, apoA |
|
| Celep et al. [64] | Control rats vs. rats treated with CCl4 | 80% methanolic extract of CC leaves | 21 d | 100, 200, 500 mg/kg BW | Partial return of SOD, CAT, GPx, MDA, TEAC (depending on the dose) |
|
| Rasoulian et al. 2012 [51] | Hamsters | Fruits | 20 d | 5, 10, 15 g/d | ↑ insulin
↓ body weight,
↓ G (only in 5 g/d) |
|
| Forman et al. [65] | Human breast cancer cells (MCF-7) | Aqueous leaf extracts | 24, 48, 72 h | 50-750 μg/mL | Antiproliferative effects |
|
| Savikin et al. [66] | In vitro HeLa cells, LS174 cells of human cancer | Fruits and leaves | NA | Not specified | Direct correlation with antioxidant capacity |
|
| Yousefi et al. [67] | In vitro tumor cells | Hydroalcoholic CC extract | NA | 5, 20, 100, 250, 500, 1000 μg/mL | Inhibition of proliferation of different tumor cells in a dose-independent manner |
|
| Leskovac et al. [55] | In vitro human lymphocytes irradiated by gamma-rays | Wild leaves air-dried, powdered | NA | Extracts 0.1-0.4 mg/mL | Lowest dose—best results
↓ radiation-induced micronuclei
↓ lipid peroxidation |
|
| Jayaprakasam et al. [68] | C57BL mice | Fruits derived and purified anthocyanin vs. ursolic acid | 8 w | 1 g/kg of anthocyani-ns and 500 mg/kg of ursolic acid | Anthocyanine mice
↓ 27% weight gain
↓ TG
↓ lipid liver accumulation
Both ↑↑ insulin |
|
